Cost-effectiveness and cost-utility of tricyclic antidepressants, selective serotonin reuptake inhibitors and lofepramine
نویسندگان
چکیده
منابع مشابه
A randomised controlled trial to compare the cost-effectiveness of tricyclic antidepressants, selective serotonin reuptake inhibitors and lofepramine.
OBJECTIVE To determine the relative cost-effectiveness of three classes of antidepressants: tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and the modified TCA lofepramine, as first choice treatments for depression in primary care. DESIGN Open, pragmatic, controlled trial with three randomised arms and one preference arm. Patients were followed up for 12 mo...
متن کاملAntidepressants in long-term therapy: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors.
OBJECTIVE Although depression has been shown to be a long-term disorder, most research studies have concentrated on its acute treatment. METHOD A literature review of the use of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) in long-term treatment of depression was performed and recommendations regarding long-term treatment were summarized. RESULTS Stud...
متن کاملSelective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability.
BACKGROUND A meta-analysis of the efficacy and tolerability of selective serotonin reuptake inhibitors (SSRIs) against tricyclic antidepressants (TCAs) in depressed patients was carried out. METHODS Efficacy data from 102 randomised controlled trials (10706 patients) were pooled to provide a summary variance-weighted effect size. Tolerability data from 95 studies (10553 patients) were combine...
متن کاملRelative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants.
BACKGROUND Selective serotonin reuptake inhibitors (SSRIs) and venlafaxine have been regarded as less toxic in overdose than tricyclic antidepressants (TCAs). Within the TCAs, dothiepin has greater toxicity. Venlafaxine may be more toxic than SSRIs. AIM To assess the toxicity in overdose of venlafaxine and SSRIs compared to TCAs, and of dothiepin compared to other TCAs. DESIGN Cohort study ...
متن کاملAdverse effects associated with selective serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis.
BACKGROUND The use of antidepressant medications and the resulting costs have increased dramatically in recent years, partly because of the introduction of selective serotonin reuptake inhibitors (SSRIs). An assessment of the clinical and economic aspects of SSRIs compared with the older tricyclic antidepressants (TCAs) was initiated to generate information for purchasers of these drugs as well...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 2006
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.188.4.337